Endocrine Abstracts

Thyroid hormones (THs) are known to regulate both lipid, glucose, and cholesterol metabolism. These effects have led to biochemical and molecular studies on the roles that they and their metabolites have on these processes. Additionally, TH analogs have been developed to improve metabolic conditions such as hypertriglyceridemia hypercholesterolemia, and obesity while minimizing side effects such as tachycardia and osteoporosis that occur in hyperthyroidism. Typically, these an...

Background: Previously, we showed that thyroid hormone (TH) supplementation reduced hepatosteatosis in patients with non-alcoholic fatty liver disease (NAFLD) and was more effective in older patients. We hypothesized that intrahepatic TH concentrations may decrease with age. To investigate this issue, we examined the effects of age on intrahepatic TH concentrations in a mouse model of NAFLD.Methods: Intrahepatic TH levels and deiodinase activity were mea...